Researchers have discovered a possible antidote for poisoning with amanita phalloides, a deadly poisonous mushroom, through tests on mice.
According to a study published in Nature Communications, the potential antidote is indocyanine green, a medical dye used in diagnostic imaging and already approved by the US FDA. Mushroom poisonings are the leading cause of food poisoning-related deaths worldwide, and the amanita phalloides is responsible for more than 90% of these deaths. Currently, there is no real antidote against this poisoning.
Researchers used CRISPR genetic screening to identify the STT3B protein as the primary culprit in Amanita phalloidae toxicity. By mining the FDA database, they discovered that indocyanine green could inhibit this protein. Preliminary tests showed that the antidote had significant potential to mitigate the toxic effects of the fungus. Researchers now plan to test indocyanine green in cases of human poisoning.
 Pascal Lemontel
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18/05/2023 | 
